Achildiev Cohen H, Zomot E, Nataniel T, Militsin R and Palty R. “The SOAR of STIM1 interacts with plasma membrane lipids to form ER-PM contact sites” Cell Reports, 2023 Mar, Vol. 42 Issue 3112238

# Research highlight – STIM1: The lord of the rings? Cell Calcium

Gataulin D, Kuperman Y, Tsoory M, Biton EI, Nataniel T, Palty R, Karbat I, Meshcheriakova A, Reuveny E. “Store-operated Ca2+ entry regulatory factor (SARAF) alters murine metabolic state in an age-dependent manner via hypothalamic pathways.“, PNAS Nexus, 2023 Mar, pgad068,


Udasin R, Sil A, Zomot E, Achildiev Cohen H, Haj J, Engelmayer N, Lev S, Binshtok AM, Shaked Y, Kienzler MA and Palty R. Photopharmacological modulation of native CRAC channels using azoboronate photoswitches PNAS 2022 ;119(13):e2118160119.

Raz Palty , CRACR2A associated immunodeficiency – the supporting factor takes center stage, Cell Calcium (2022), doi:


Zomot E, Achildiev Cohen H, Dagan I, Militsin R, and Palty R. Bidirectional regulation of calcium release–activated calcium (CRAC) channel by SARAF. J Cell Biol. (2021) 220 (12): e202104007.

Dagan I and Palty R. Regulation of Store-Operated Ca2+ Entry by SARAF. Cells 2021, 10(8), 1887

Mekies LN, Regev D, Eisen B, Fernandez-Gracia J, Baskin P, Ben Jehuda R, Shulman R, Reiter I, Palty R, Arad M, Gottlieb E, Binah O. Depressed β-adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients’ induced pluripotent stem cell-derived cardiomyocytes. J Cell Mol Med. 2021 Apr;25(8):3922-3934

Kimberlin CR, Meshcheriakova A, Palty R, Raveh A, Karbat I, Reuveny E, Minor DL Jr. SARAF Luminal Domain Structure Reveals a Novel Domain-Swapped β-Sandwich Fold Important for SOCE Modulation. JMB.2019 Jul 12;431(15):2869-2883.


Rogers EJ, Jada R, Schragenheim-Rozales K, Sah M, Cortes M, Florence M, Levy NS, Moss R, Walikonis RS, Palty R, Shalgi R, Lichtman D, Kavushansky A, Gerges NZ, Kahn I, Umanah GKE, Levy AP. An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors. Front Mol Neurosci. 2019 Feb 20;12:43

Palty R*, Fu Z, Isacoff EY*. Sequential steps of CRAC channel activation Cell Reports. 19(9):1929-1939. 2017 *corresponding author
Palty R, Isacoff EY.  Cooperative STIM1 binding to the N’ and C’ termini of Orai1 gates and modulates CRAC channels JBC 291(1):334-41. 2016
Palty R, Stanley C, Isacoff EY.  Critical role for Orai1 C-terminal and TM4 in gating of CRAC channels. Cell Research. 25 (8):963-80. 2015
Bharill S, Fu Z, Palty R, Isacoff EY.  Stoichiometry and specific assembly of Best ion channels. PNAS 111(17):6491-6. 2014

Palty R, Shoshan-Barmatz V. Mitochondrial Na+/Ca2+ exchange assays. Cold Spring Harbor Protocols. 2014(2):202-6. 2014

Ben-Hail D, Palty R, Shoshan-Barmatz V.  Measurement of mitochondrial Ca2+ transport as mediated by VDAC1, by the Na+/Ca2+ exchanger and by the Ca2+ uniporter. Cold Spring Harbor Protocols. 2014(2):161-6. 2014

Palty R, Raveh A, Kaminsky I, Meller R, Reuveny E.  SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling. Cell  149(2):425-38. 2012

# Research Highlight: Stop refilling Ca2+ stores. Nat Rev Mol Cell Biol.

Palty R*, Sekler I*. The mitochondrial Na(+)/Ca(2+) exchanger. Cell Calcium. 52(1):9-15. 2012

Palty R*, Hershfinkel M, Sekler I*.  Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchanger. JBC. 287(38):31650-7. 2012
*corresponding author

Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, Nolte C, Fishman D, Shoshan-Barmatz V, Herrmann S, Khananshvili D, Sekler I.  NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. PNAS 107(1):436-41. 2010


Palty R, Hershfinkel M, Yagev O, Saar D, Barkalifa R, Khananshvili D, Peretz A, Grossman Y and I Sekler. Single alpha-domain constructs of the Na+/Ca2+ exchanger, NCLX, oligomerize to form a functional exchanger. Biochemistry 45:11856-66, 2006
Palty R, Ohana E, Hershfinkel M, Volokita M, Elgazar V, BaharirO, Silverman WF, Argaman M and I. Sekler. Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger. JBC 279:25234-40, 2004

Ohana E, Segal D, Palty R, Ton-That D, Moran A, Sensi SL, Weiss JH, Hershfinkel M and I Sekler. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. JBC 279:4278-84, 2004